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Researchers find common immune system mechanism between pregnancy, cancer - EurekAlert
Researchers from the University of Michigan Rogel Cancer Center found a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer’s growth. Looking at mouse models and cell lines of breast and gynecologic cancers, the researchers identified the hormone progesterone as a key regulator of the B7-H4 immune checkpoint.Researchers from the University of Michigan Rogel Cancer Center found a molecular mechanism, shared in cancer and pregnancy, that suppresses the immune system. Block this mechanism, called B7-H4, and the immune system revs up to slow cancer’s growth. Looking at mouse models and cell lines of breast and gynecologic cancers, the researchers identified the hormone progesterone as a key regulator of the B7-H4 immune checkpoint.
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