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Melanomas resist drugs by 'breaking' genes - EurekAlert


<p>A study published today in the journal <em>Cell Reports</em> has disentangled the mechanisms behind one of the ways melanoma cancer cells develop resistance to treatment. The study found that, in response to some drugs, melanomas can &lsquo;break&rsquo; parts of their BRAF gene, which is mutated in 1 in 2 melanomas. This helps the tumour create alternative versions of the protein which lack regions targeted by one BRAF inhibitors, one of the main drugs used to treat this type of cancer,&nbsp;making treatment less effective. The findings pave the way for alternative strategies to treat BRAF-mutated melanoma, which leads to relapse in 50% of patients within a one-year period.</p>

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