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Immunogenicity of human-induced pluripotent stem cell-derived cardiomyocyte sheets - EurekAlert
Human induced pluripotent stem (hiPS) cells refer to stem cells derived from adult somatic cells like blood or skin cells. hiPS-derived cardiomyocytes (hiPC-CMs) have shown promise in treating ischemic heart disease. However, their clinical application is limited by an incomplete understanding of their immunogenicity. Now, researchers from Juntendo University developed a humanized mice model and elucidated the role of CD8+ T cells in regulating the immune response against hiPS-CMs.
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