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What is the optimal size that is more likely to accumulate in brain tumors selectively? - EurekAlert
- Using nanoruler technology, the optimal size more likely to accumulate in brain tumors was studied. - The size effect of nanomedicine on passive GBM targeting with size-tunable poly(ethylene glycol)-grafted copolymers (gPEGs) as polymeric nanorulers was explored. - It was demonstrated that the threshold for brain tumor tissue permeability was in the range of 10 to 30nm. - By adjusting the size of the gPEGs to 10 nm, an unprecedentedly high brain tumor accumulation was obtained (19 times higher than that in the normal brain region and 4.2 times higher than that of 30 nm of gPEGs). - The size-optimized gPEGs can be loaded with contrast agents or anti-cancer drugs to enable more effective cancer diagnostics or treatments.
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