What is post-SSRI Sexual Dysfunction (PSSD) and what do I need to know about it?

SSRI can negatively affect neurosteroidgenesis and alter levels of oxysterol in mice brain, which has been observed in similar experimental model of multiple sclerosis and diabetic encephalopathy. This could explain Post-SSRI Sexual Dysfunction.

In 2019, the European Medicine Agency finally concluded that antidepressant can have long lasting impact on sexual functioning even after discontinuation, this syndrome is referred to as PSSD (Post SSRI Sexual Dysfunction). (Page 5 of Link)

Psilocybin Therapy Combined With SSRI Antidepressants Is Possible, COMPASS Study Confirms