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USC-led study introduces a new and improved way to grow the cells that give rise to the kidney's filtration system - EurekAlert
<p>In a new study published in<em> Cell Stem Cell</em>, USC scientists report significant progress in cultivating nephron progenitor cells (NPCs), the cells destined to form the kidney’s filtration system, the nephrons. NPCs hold immense promise for understanding kidney development, modeling diseases, and discovering new treatments. The team improved the chemical cocktail for generating and growing NPCs in the laboratory, enabling the sustained growth of both mouse and human NPCs in a simple 2-dimensional format. This marks a major improvement over the previous 3-dimensional system, which was not only more cumbersome, but also limited the ability to perform genome editing on the cells. The cocktail also enables the expansion of induced NPCs (iNPCs) from human pluripotent stem cells. This approach will facilitate the creation of patient-specific kidney disease models and enhance efforts to identify nephron targeted drugs.</p>
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