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Update on the STING signaling pathway in developing nonalcoholic fatty liver disease - EurekAlert
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, affecting about 25% of the global population due to the increasing rates of obesity and metabolic syndrome. NAFLD encompasses a spectrum of liver conditions ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite its prevalence, there are limited effective treatment options available. Inflammation driven by metabolic disturbances is a key factor in the development and progression of NAFLD. Recent research has highlighted the role of the stimulator of interferon genes (STING) signaling pathway in mediating hepatic inflammation and metabolic disorders, making it a potential target for therapeutic intervention.
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