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Unveiling a novel AAK1 inhibitor: How chemical proteomics unlocked therapeutic potential - EurekAlert
Understanding protein kinases' role in diseases like cancer is crucial for drug development. Researchers from Okayama University have introduced a novel inhibitor, targeting Adaptor Protein 2-Associated Protein Kinase 1 (AAK1). Utilizing Kinobeads technology, they elucidated TIM-063's binding to AAK1's catalytic domain, laying the groundwork for targeted inhibition. This research offers promising avenues for drug discovery, potentially addressing conditions such as schizophrenia, Parkinson's disease, and viral infections with more efficient enzyme inhibitors.
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