Get the latest Science News and Discoveries

Unveiling a novel AAK1 inhibitor: How chemical proteomics unlocked therapeutic potential - EurekAlert


Understanding protein kinases' role in diseases like cancer is crucial for drug development. Researchers from Okayama University have introduced a novel inhibitor, targeting Adaptor Protein 2-Associated Protein Kinase 1 (AAK1). Utilizing Kinobeads technology, they elucidated TIM-063's binding to AAK1's catalytic domain, laying the groundwork for targeted inhibition. This research offers promising avenues for drug discovery, potentially addressing conditions such as schizophrenia, Parkinson's disease, and viral infections with more efficient enzyme inhibitors.

None

Get the Android app

Or read this on Eureka Alert

Read more on:

Photo of novel AAK1 inhibitor

novel AAK1 inhibitor

Photo of EurekAlert

EurekAlert

Photo of chemical proteomics

chemical proteomics

Related news:

News photo

Autophagy in pancreatitis - EurekAlert

News photo

Shaping the circular bioeconomy in Tennessee - EurekAlert

News photo

New resource pinpoints inner workings of sorghum plant cells - EurekAlert