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Unraveling the role of ADGRF5: Insights into kidney health and function - EurekAlert
The absence of Adhesion G-protein-coupled receptor F5 (ADGRF5) led to significant changes in gene expression in glomerular endothelial cells, disrupting the structure and function of the glomerular filtration barrier, as discovered by researchers from Tokyo Tech and Kyorin University. Their study, employing genetic knockout and knockdown techniques in mice and human cells, elucidates ADGRF5's crucial role in barrier maintenance and proposes potential therapeutic approaches for glomerular diseases.
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