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Unlocking RNA functionality: A redox-responsive approach - EurekAlert
National University of Singapore (NUS) chemists have developed a strategy using disulfide-containing small molecules to facilitate the reversible control and delivery of ribonucleic acid (RNA). A research team led by Assistant Professor Zhu Ru-Yi from the NUS Department of Chemistry has developed a method that takes advantage of a chemical process called post-synthetic RNA acylation chemistry, and combined it with dynamic disulfide exchange reaction for RNA delivery and reversible control. This method provides a way to mask the RNA molecule, and researchers can potentially regulate its activity and delivery until it reaches its target site within the cell.
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