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Targeting “monster cancer cells” could reduce recurrence rates after cancer therapy - EurekAlert


Scientists have begun to uncover the role of polyploid giant cancer cells in cancer recurrence. In the Journal of Biological Chemistry, a Medical University of South Carolina team shows that cancer cells, when stressed by therapy, can transform into non-dividing PGCCs, only to regain their ability to divide later, setting the stage for recurrence. The team also identified existing drugs with potential to reduce recurrence rates by preventing the switch from PGCCs to dividing cells.

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