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Successful murine model of dermatomyositis reveals underlying immune system involvement - EurekAlert
<p>Researchers from Tokyo Medical and Dental University (TMDU) have developed a murine model of “anti-MDA5 positive dermatomyositis”, a rare, progressive autoimmune disease with a high mortality rate. This model provides a tool for understanding the underlying disease pathogenesis and identifying novel therapeutic targets. They identified components of the immune system—CD4-positive T cells and interleukin-6—as key in the development of associated lung fibrosis, and showed that intervention to reduce their levels can ameliorate disease development.</p>
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