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Science tested 64 natural remedies for depression—only a few actually work

Over-the-counter (OTC) products like St John’s Wort and omega-3s have long been touted for helping with depression, but new research reveals that 64 different OTC products have been tested in clinical trials, with varying levels of evidence. Some well-known options like St John’s Wort, saffron, and probiotics showed encouraging results, sometimes comparable to antidepressants. Others like folic acid, lavender, and lemon balm show emerging promise. Although few safety concerns were reported, researchers stress the need for better safety reporting and more studies, especially on commonly used but understudied herbal remedies.

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