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Role of fibrinogen-like protein 1 in tumor recurrence following hepatectomy - EurekAlert
Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits a dismal five-year survival rate of only 18%. Major contributing factors to HCC include viral hepatitis infections and nonalcoholic fatty liver disease. Despite advancements in chemotherapy and radiotherapy, which have shown efficacy in controlling HCC, these treatments are often accompanied by severe side effects. As a result, surgical interventions such as liver transplantation and partial hepatectomy (PH) remain the primary therapeutic strategies, particularly in the early stages of HCC. Among these, PH is crucial due to the scarcity of suitable organs for transplantation. However, a significant drawback of PH is the high rate of tumor recurrence, with about 70% of patients experiencing recurrence within five years.
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