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Postpartum depression after adolescent stress shows a dysregulated HPA axis: a cross-species translational study - EurekAlert
<p>Researchers report that stress from adolescent social isolation in mice elicits a prolonged elevation of corticosterone levels and glucocorticoid signaling, which in turn results in long-lasting postpartum behavioral changes indicative of depression. Importantly for clinically relevant biology, this was associated with prolonged dysregulation of the neuro-hormone system that manages stress, called the hypothalamic-pituitary-adrenal, or HPA, axis.</p>
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