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Phage-derived enzyme targets E. faecalis biofilms to mitigate acute graft-versus-host disease - EurekAlert


Researchers from Japan discover a new enzyme with promising antibacterial activity   Acute graft-versus-host disease (aGVHD) is a medical condition that occurs when donor immune cells attack the recipient's tissues after an allogeneic hematopoietic stem cell transplantation (allo-HCT). The pathogenesis of aGVHD is influenced by gut dysbiosis and Enterococcus domination. Researchers from Japan recently identified a bacteriophage-derived enzyme called endolysin capable of targeting biofilms formed by Enterococcus faecalis. Their findings offer hope for tailored interventions in allo-HCT.

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