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One-step synthesis of pharmaceutical building blocks: new method for anti-Michael reaction - EurekAlert
The anti-Michael addition reaction, which involves nucleophilic addition reactions to the α-position of α,β-unsaturated carbonyl compounds, has been difficult to achieve so far. In a new study, researchers from Japan have developed a new method for successful anti-Michael addition reaction of α-unsaturated carbonyl compounds, which are commonly used in pharmaceuticals. This reaction is expected to be used as a one-step synthesis method with 100% atomic efficiency for α-unsaturated carbonyl compounds.
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