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Novel mechanism for targeting bone marrow adipocytes to prevent bone loss - EurekAlert

The team found that absence of estrogen-related receptor α (ESRRA) in bone marrow adipocytes alters secreted factors, affecting BMSCs fate and vascular endothelial cells. Published in Nature Communications, this suggests ESRRA as a potential osteoporosis treatment target, with knockout in mice rescuing bone loss and vessel distortion induced by ovariectomy or obesity, potentially mitigating marrow adiposity and promoting bone formation through leptin regulation.

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