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New method for safe and efficient cell transfection developed by SIAT researchers - EurekAlert
Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, in collaboration with Duke University, have developed a novel method for transfection that enhances the permeability of cell and nuclear membranes. The researchers used acoustic and thermal effects on cells to achieve safe, efficient, and high-throughput transfection of stem and primary T cells. The study found that the proposed acoustothermal transfection device significantly enhanced cell membrane permeability and could deliver multiple types of plasmids into hard-to-transfect cells with high efficiency. The process demonstrated high cell viability and showed potential for future cellular and gene therapies.
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