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New insights into osteoporosis - EurekAlert
Researchers from Osaka University have identified that the loss of the Men1 gene is key in the development of osteoporosis, fragile bones occurring with age. They developed a mouse model of age-related cellular aging, or ‘senescence’, in the bone for the first time. This showed that cellular senescence of bone-forming osteoblasts leads to osteoporosis due to an imbalance between the activities of bone formation and bone resorption, opening avenues for drug intervention and novel treatments.
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