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Multipurpose Vaccine Shows New Promise in the Presence of Pre-Existing Immunity

A new study in animal models confirms the efficacy of a mosaic nanoparticle vaccine developed at Caltech in eliciting broadly cross-reactive antibodies against multiple coronaviruses despite previous vaccination with a COVID-19 vaccine, suggesting that the phenomenon of "original antigenic sin" does not diminish the efficacy of the vaccine candidate.

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