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Mitochondrial phosphate carrier plays an important role in virulence of Candida albicans - EurekAlert
In a paper published in Mycology, Professor Yan Wang's team found that in both nematode and murine infection models, the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans. Further studies showed that virulence defects were associated with defects in hyphal formation and reactive oxygen species (ROS) production. This study shows that MIR1 plays an important role in C. albicans mitochondrial function, filamentation and virulence, and may be a promising antifungal target.
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