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Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients - EurekAlert
Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, beginning with dysplastic nodules (DNs) and early HCC, progressing to overt HCC. Recent advancements in liver imaging, particularly the use of hepatocyte-specific contrast agents, have enhanced the detection of these precursor lesions, known as borderline hepatic nodules. These nodules, especially those hypointense in the hepatobiliary phase (HBP) without arterial phase hyperenhancement (APHE), present a diagnostic challenge and a significant risk of malignant transformation.
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