Get the latest Science News and Discoveries
It takes two to TANGO: New strategy to tackle fibrosis and scarring - EurekAlert
A study by researchers at the Center for Genomic Regulation (CRG) and University of Cologne is the first to successfully control the effects of collagen hypersecretion at the cellular level. The experimental treatment consists of designer peptides which interrupt the interaction between TANGO1 and cTAGE5, two proteins important for collagen secretion. Experiments with patient-derived human cells and zebrafish showed the peptides are effective, non-toxic, and their effects reversible. The results pave the way for the development of new treatments that improve the cosmetic effects of scarring, relieve the symptoms of autoimmune diseases such as scleroderma, or help prevent the development of fibrosis, a more serious condition attributed to 45% of deaths in the industrialised world.
None
Or read this on Eureka Alert