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Inspired by nature: synthetic nightshade molecule effective against leukemia cells - EurekAlert
Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells. Using state-of-the-art chemical and genetic high-throughput analyses, the team led by Georg Winter not only confirmed its effectiveness but also elucidated its mechanism of action: the molecule disrupts the cholesterol metabolism of tumor cells. The study's findings were published in the journal Nature Chemical Biology (DOI 10.1038/s41589-024-01614-4).
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