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Innovative CMUT-based resonant biosensor offers enhanced DNA detection specificity - EurekAlert
This study presents a groundbreaking approach to label-free DNA detection using capacitive micromachined ultrasonic transducers (CMUTs) integrated with a CMOS front-end interface. The biosensor is designed for high-performance and miniaturized applications, overcoming the limitations of conventional methods through efficient functionalization on aluminum electrodes. The use of ethylene-glycol alkanethiols facilitates the detection of single-stranded DNA oligonucleotides with large specificity, demonstrating improved selectivity through fluorescence imaging technology. The sensor array is characterized using a lumped equivalent model, and the application-specific integrated circuit chip is developed to generate on-chip high voltage with low power consumption. The successful demonstration of label-free DNA biosensing under dry conditions using a microfabricated CMUT array with a 2 MHz frequency on CMOS electronics opens up new possibilities for full-on-chip DNA analysis, paving the way for more accessible and accurate point-of-care diagnostics.
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