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How the body switches out of “fight” mode - EurekAlert

<p><strong>Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions. But previously, astonishingly little was known about how they exactly do that. A team of researchers from Charit&eacute; &ndash; Universit&auml;tsmedizin Berlin, Uniklinikum Erlangen and Ulm University have now explored the molecular mechanism of action in greater detail. As the researchers report in the journal <em>Nature</em>,* glucocorticoids reprogram the metabolism of immune cells, activating the body&rsquo;s natural &ldquo;brakes&rdquo; on inflammation. These findings lay the groundwork for development of anti-inflammatory agents with fewer and less severe side effects.</strong></p>

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