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Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51 (2024)


Liu et al. find that long-chain acyl-coenzyme A activates two mitochondrial fission proteins, MiD49 and MiD51, by inducing their oligomerization. This activates their ability to stimulate DRP1 GTPase activity and triggers mitochondrial division.

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Photo of MiD51

MiD51

Photo of coenzyme A

coenzyme A

Photo of MiD49

MiD49