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Exploring the potential causal effects of myopia: A phenome-wide Mendelian randomization association study (2024)

Myopia is a leading cause of visual impairment worldwide, whose pathogenesis remains poorly understood. We comprehensively performed phenome-wide Mendelian randomization analysis (MR-PheWAS) to explore causal factors and potential therapeutic targets for myopia in participants from the UK Biobank study. The analysis revealed that 55 robust associations (1 disease, 2 employment, 3 cognitive functions, 4 sex-specific factor, 4 mental health, 5 lifestyle and environment, 10 sociodemographic, 12 physical measures and 14 ocular measures/conditions phenotypes) were significantly causally correlated with myopia. The results indicate that myopia may be influenced by several factors, such as serum metabolic traits, fatty acids intake, fat-related indexes, mental health, as well as some previously acknowledged risk factors. Future clinical trials are needed to verify our results. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement This study did not receive any funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study used (or will use) ONLY openly available human data that were originally located at:https://gwas.mrcieu.ac.uk/datasets/ I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors <https://gwas.mrcieu.ac.uk/>

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