Seattle is a seaport city on the West Coast of the United States. It is the seat of King County, Washington. With a 2020 population of 737,015, it is the largest city in both the state of Washington and the Pacific Northwest region of North America. The Seattle metropolitan area's population is 4.02 million, making it the 15th-largest in the United States. Its growth rate of 21.1% between 2010 and 2020 makes it one of the nation's fastest-growing large cities. Seattle is situated on an isthmus between Puget Sound and Lake Washington. It is the northernmost major city in the United States, located about 100 miles south of the Canadian border. A major gateway for trade with East Asia, Seattle is the fourth-largest port in North America in terms of container handling as of 2021. The Seattle area was inhabited by Native Americans for at least 4,000 years before the first permanent European settlers.