Remdesivir

Remdesivir, sold under the brand name Veklury, is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein. During the COVID‑19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID‑19 in numerous countries. Remdesivir was originally developed to treat hepatitis C, and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID‑19. Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. The most common side effect in healthy volunteers is raised blood levels of liver enzymes. The most common side effect in people with COVID‑19 is nausea.

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When is remdesivir effective for COVID-19?

Remdesivir reduces COVID-19 mortality in a real-world setting

Remdesivir-resistant version of COVID-19 detected in organ transplant recipients

COVID-19 Treatment Remdesivir Dominated Hospital Drug Spending in 2021

Study shows effectiveness of pill form of remdesivir to treat COVID-19 in mice

Rethinking remdesivir: Researchers modify current drug, creating oral version that can be taken earlier in COVID-19 diagnoses

Association of remdesivir treatment with survival, length of hospital stay among US veterans hospitalized with COVID-19

Neither remdesivir nor HCQ affect viral clearance in hospitalized patients with COVID-19

Remdesivir in COVID-19: Indication of considerable added benefit for a part of the patients

Case report: Remdesivir induced dangerously low heart rate in COVID-19 patient

SARS-CoV-2 research: Second possible effective mechanism of remdesivir discovered

When Combined With Hepatitis C Drugs, Antiviral Remdesivir May Be 10 Times More Effective Against COVID-19

Hepatitis C drugs combined with Remdesivir show strong effectiveness against COVID-19, study finds

Hepatitis C drugs combined with Remdesivir show strong effectiveness against covid-19

Hepatitis C drugs boost Remdesivir's antiviral activity against COVID-19

Hepatitis C drugs multiply effect of COVID-19 antiviral Remdesivir

Remdesivir and clinical improvement in hospitalized patients with COVID-19

The Strange Story Of Remdesivir, A Covid Drug That Doesn’t Work

Remdesivir disrupts COVID-19 virus better than other similar drugs