Maryland is a state in the Mid-Atlantic region of the United States, bordering Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean to its east. Baltimore is the largest city in the state and the capital is Annapolis. Among its occasional nicknames are Old Line State, the Free State, and the Chesapeake Bay State. It is named after the English Queen Henrietta Maria, known in England as Queen Mary, who was the wife of King Charles I. Before its coastline was explored by Europeans in the 16th century, Maryland was inhabited by several groups of Native Americans - mostly by the Algonquin, and to a lesser degree by the Iroquois and Sioux. As one of the original Thirteen Colonies of England, Maryland was founded by George Calvert, 1st Baron Baltimore, a Catholic convert who sought to provide a religious haven for Catholics persecuted in England.