Gene Therapy

Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. It is thought to be able to cure many genetic disorders or treat them over time. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in phase I. In 2003, Gendicine became the first gene therapy to receive regulatory approval.

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Gene therapy hailed as ‘medical magic wand’ for hereditary swelling disorder

Gene therapy cures hereditary deafness in two people

Gene therapy restores hearing in children with hereditary deafness

Gene Therapy Allows an 11-Year-Old Boy to Hear for the First Time

Base editing, a new form of gene therapy, sharply lowers bad cholesterol in clinical trial

Redefining Gene Therapy: CRISPR’s Innovative “Find-and-Replace” Genome Editing

New methods for effective transport of large genes in gene therapy

New Trials Aim to Restore Hearing in Deaf Children—With Gene Therapy

Researchers design gene therapy that can effectively target glioblastoma

The first gene therapy for muscular dystrophy has been approved for some kids

Triplex Origami: A Game-Changer in Gene Therapy and DNA Nanotechnology

Study reveals effective gene therapy for long-term contraception in domestic cats

Gene therapy produces long-term contraception in female domestic cats

A gene therapy shot might keep cats from getting pregnant without being spayed

Revolution in Pet Sterilization: Gene Therapy Offers Long-Term Contraception for Cats

Hello kitty, goodbye kittens? Gene therapy spays cats without surgery

Researchers design an innovative strategy to fight obesity through gene therapy

Gene Therapy Breakthrough in Treatment of Age-Related Hearing Loss

Muscular dystrophy gene therapy nears approval, but safety concerns linger

Gene Therapy in the Womb Is Inching Closer to Reality