Cyprus, officially the Republic of Cyprus, is an island country in the eastern Mediterranean Sea south of the Anatolian Peninsula. Continentally, it is often placed in Western Asia while being culturally tied to Southeast Europe. It is the third-largest and third-most populous island in the Mediterranean, and is south of Turkey, east of Greece, and west of Syria. Its capital and largest city is Nicosia. The earliest known human activity on the island dates to around the 10th millennium BC. Archaeological remains from this period include the well-preserved Neolithic village of Khirokitia, and Cyprus is home to some of the oldest water wells in the world. Cyprus was settled by Mycenaean Greeks in two waves in the 2nd millennium BC. As a strategic location in the Eastern Mediterranean, it was subsequently occupied by several major powers, including the empires of the Assyrians, Egyptians and Persians, from whom the island was seized in 333 BC by Alexander the Great.