Combe Grenal, also known as Combe-Grenal, is an archeological site consisting of a collapsed cave and a slope deposit near Domme, Dordogne in Dordogne, France. It dates back to c. 130,000 to 50,000 Before Present. First described by François Jouannet in 1812, it was again briefly described by Édouard Lartet and Henry Christy in "Cavernes du Perigord" published in Revue archéologique in 1864. In the 1930s, D. and E. Peyrony did excavations, but the cave was first thoroughly excavated by François Bordes from 1953 to 1965. The site's stratigraphic sequence is 13 meters in depth and has 64 layers. 55 layers are Mousterian while the 9 layers near the bottom are Acheulean. The oldest layers dates back to the end of the Riss glaciation and the youngest to the Würm glaciation. The oldest Neanderthal remains was found in layer 60. There are also found remains in level 39 and 35.

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