Bipolar Disorder

Bipolar disorder, previously known as manic depression, is a mood disorder characterized by periods of depression and periods of abnormally elevated happiness that last from days to weeks each. If the elevated mood is severe or associated with psychosis, it is called mania; if it is less severe, it is called hypomania. During mania, an individual behaves or feels abnormally energetic, happy or irritable, and they often make impulsive decisions with little regard for the consequences. There is usually also a reduced need for sleep during manic phases. During periods of depression, the individual may experience crying and have a negative outlook on life and poor eye contact with others. The risk of suicide is high; over a period of 20 years, 6% of those with bipolar disorder died by suicide, while 30–40% engaged in self-harm. Other mental health issues, such as anxiety disorders and substance use disorders, are commonly associated with bipolar disorder.

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Evidence of brain changes in those at risk of bipolar disorder captured with MRI scans

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An algorithm may help clinicians recognize patients with bipolar disorder who are misdiagnosed with depression

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Recently Evolved Region of the “Dark Genome” Offers Clues to Treatment of Schizophrenia and Bipolar Disorder

Lithium imaging method could shine new light on bipolar disorder, treatment

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Study identifies genetic risks for suicide death in individuals with bipolar disorder

DNA methylation changes and characteristics in neurons of bipolar disorder patients

Additional genetic risk variants behind bipolar disorder have emerged

Over 60 Genetic Links to Bipolar Disorder Identified in Largest Study to Date

Researchers identify 64 regions of the genome that increase risk for bipolar disorder

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Blood test for depression, bipolar disorder

Blood Test Developed to Detect Depression and Bipolar Disorder

IU School of Medicine researchers develop blood test for depression, bipolar disorder