In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Biomarkers are used in many scientific fields. Digital biomarkers are a novel emerging field of biomarkers, mostly collected by smart biosensors. So far, digital biomarkers have been focusing on monitoring vital parameters such as accelerometer data and heartrate but also speech. Novel non-invasive, molecular digital biomarkers are increasingly available recorded by e.g. on-skin sweat analysis, which can be seen as next-generation digital biomarkers. Digital biomarkers can be easily shared with the responsible physician, and novel diagnostics approaches can be developed using artificial intelligence.