AlphaFold is an artificial intelligence program developed by Alphabet's/Google's DeepMind which performs predictions of protein structure. The program is designed as a deep learning system. AlphaFold AI software has had two major versions. A team of researchers that used AlphaFold 1 placed first in the overall rankings of the 13th Critical Assessment of protein Structure Prediction in December 2018. The program was particularly successful at predicting the most accurate structure for targets rated as the most difficult by the competition organisers, where no existing template structures were available from proteins with a partially similar sequence. A team that used AlphaFold 2 repeated the placement in the CASP competition in November 2020. The team achieved a level of accuracy much higher than any other group.

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Has AlphaFold actually solved biology’s protein-folding problem?