Acesulfame

Acesulfame potassium, also known as acesulfame K or Ace K, is a synthetic calorie-free sugar substitute often marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG. In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3-oxathiazine-4-one 2,2-dioxide. It is a white crystalline powder with molecular formula C ₄H ₄KNO ₄S and a molecular weight of 201.24 g/mol.

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Artificial Sweeteners Sucralose(Splenda) and Acesulfame Potassium(Ace-K) impact detoxification in the liver and likely bind to PGP, and might be problematic for people who take medications (antidepressants, antibiotics and blood pressure pills) that use PGP as a primary detoxification transporter.