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Design and development of a novel light sheet fluorescence microscope - EurekAlert
Three-dimensional (3D) imaging enables the accurate visualization of internal tissues and provides important structural information at the cellular level. However, imaging techniques like light sheet fluorescence microscopy (LSFM) are inaccessible due to their high cost and complexity. To address these obstacles, Juntendo University team from Japan developed a new LSFM system called descSPIM — desktop-equipped selective plane illumination microscopy (SPIM) for cleared tissue sample imaging. Its promising applications were further validated in animal studies.
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