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CRISPR uncovers gene that supercharges vitamin D—and stops tumors in their tracks

A gene called SDR42E1 has been identified as a key player in how our bodies absorb and process vitamin D. Researchers found that disabling this gene in colorectal cancer cells not only crippled their survival but also disrupted thousands of other genes tied to cancer and metabolism. This opens the door to highly targeted cancer therapies—by either cutting off vitamin D supply to tumors or enhancing the gene’s activity to boost health. The findings hint at vast possibilities in treating diseases influenced by vitamin D, though long-term impacts remain uncertain.

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