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Choosing outcomes: new switchable process for synthesizing 3-aminoindolines and 2'-aminoarylacetic acids from ... - EurekAlert


Organic reaction protocols where tweaking the reaction conditions can give rise to two very different economically viable final products have always piqued the interest of chemists. Recently, researchers from Japan presented a new switchable procedure for deriving 3-aminoindolines and 2’-aminoarylacetic acids, two valuable pharmaceutical molecules, from the same substrate and reagents in the presence of Grignard reagent by taking advantage of chameleonic tautomerism. This procedure exhibited a high chemoselectivity and resulted in high yields.

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