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Charité study in Nature: How cells deal with extra chromosomes - EurekAlert
Having extra chromosomes is typically an issue for an organism and can disrupt development or cause disease. But some cells benefit instead: For example, cancer cells or pathogenic yeasts can use extra chromosomes to escape treatment and become drug-resistant. A team of researchers from Charité – Universitätsmedizin Berlin has now deciphered how yeasts manage to compensate for the genetic imbalance. Their findings, published in the journal Nature,* could yield new approaches to dealing with treatment-resistant tumors or fungal infections.
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