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Breaking down barriers: ROCK2 inhibition facilitates drug delivery in fibrotic pancreatic cancer - EurekAlert


In a pioneering study, scientists at Okayama University developed a human pancreatic cancer fibrotic barrier 3D cell-culture model to assess treatments for pancreatic ductal adenocarcinoma. By targeting the ROCK2 pathway, they achieved a notable decrease in fibrosis and enhanced tissue permeability to drugs, offering promising avenues for overcoming treatment obstacles in pancreatic cancer. This innovative strategy has the potential to transform therapeutic interventions, representing a pivotal advancement in tackling this formidable disease.

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