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Boosting CAR-T cell therapies from under the skin - EurekAlert
CAR-T cell therapies are transforming the treatment of previously incurable blood cancers, but a large proportion of patients still responds only poorly or not at all to them, calling for new strategies to overcome this challenge. Now, a research team at the @Wyss developed a simple intervention in the form of a biodegradable scaffold material called “T-cell enhancing scaffolds” (TES) that can be locally injected under the skin and used to restimulate CAR-T cells after their administration. This increased their therapeutic efficacy and significantly curbed tumor growth and prolonged animal survival in an aggressive mouse lymphoma model.
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