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Active plant substance reduces pulmonary hypertension - EurekAlert
Pulmonary hypertension is a very serious disease that leads to heart failure and death in many patients. Searching for new treatment options, a team headed by Professor Daniela Wenzel and Dr. Alexander Seidinger from the Department of Systems Physiology at Ruhr University Bochum, Germany, tested the plant substance FR900359 – referred to as FR by the researchers. It differs from previously used active substances in that it targets a different point in the signaling pathway that leads to pulmonary hypertension. As a result, it simultaneously inhibits numerous factors that lead to vasoconstriction in the lungs. “In our experiments, FR relaxed the vessels quickly and effectively and produced a good therapeutic effect,” as Alexander Seidinger, first author of the study, outlines the findings. The results were published in the journal EMBO Molecular Medicine on July 8, 2024.
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