Get the latest Science News and Discoveries

A shortcut for drug discovery - EurekAlert


<p><strong>For most human proteins, there are no small molecules known to bind them chemically (so called &ldquo;ligands&rdquo;). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal <em>Science </em>(DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community. </strong></p>

None

Get the Android app

Or read this on Eureka Alert

Read more on:

Photo of shortcut

shortcut

Photo of Drug discovery

Drug discovery

Photo of EurekAlert

EurekAlert

Related news:

News photo

Cancer survivors reporting loneliness experience higher mortality risk, new study shows - EurekAlert

News photo

Découverte de cancers d’origine épigénétique - EurekAlert

News photo

Bloody net - EurekAlert