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A Chinese team reveals how acetylation regulates centromere dynamics, chromosome segregation and mitotic ... - EurekAlert
In a paper published in SCIENCE CHINA Life Sciences, a Chinese team reveals a molecular mechanism by which the acetylation and deacetylation cycle of Bub1 regulates chromosome congression and segregation. In early mitosis, Bub1 acetylation enhances its kinase activity, leading to the phosphorylation of histone H2A at T120, which in turn facilitates the recruitment of the CPC complex and Sgo1 to the centromeres. This process is pivotal for faithful chromosome congression and segregation during mitosis. When cells exit mitosis, HDAC1-regulated deacetylation of Bub1 decreases H2ApT120 levels and thereby promotes the departure of centromeric CPC and Sgo1, ensuring timely centromere disassembly.
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