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‘Invisible’ protein keeps cancer at bay - EurekAlert
Scientists at the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, in collaboration with research groups from the Center for Experimental Medicine Institute of Tumor Biology and the Martini Clinic at the University Medical Center Hamburg-Eppendorf (UKE), and the Leibniz Institut on Aging - Fritz Lipmann Institute in Jena, discovered a new molecular mechanism that counteracts one of the main cancer-promoting proteins. In this mechanism, an unstructured protein, essentially invisible to structural biology techniques, disables the cancer-promoting protein by gluing its molecules into a stack. Data from human cancer cell lines and cancer samples from a diverse cohort of patients support the role of this mechanism in cancer progression. The study mostly focused on prostate cancer, the second most common cancer in men. However, the scientists expect that the mechanism might play a role in other types of cancer as well.
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