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Presynaptic homeostasis mediated by exocytosis of a SNARE protein


Experiments show that when subjected to high-frequency stimulation, excitatory neurons exhibit a presynaptic form of homeostatic plasticity mediated by the exocytosis of v-SNARE protein VAMP7 and the resulting inhibition of P/Q-type calcium channels.

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Photo of SNARE

SNARE

Photo of SNARE protein

SNARE protein

Photo of exocytosis

exocytosis